Structure of PDB 3plf Chain D Binding Site BS01

Receptor Information
>3plf Chain D (length=301) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTI
LSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPR
RNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKT
IVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLF
QPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCT
RLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPD
L
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3plf An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
Resolution1.92 Å
Binding residue
(original residue number in PDB)		S80 P81 Y274 R294 S296 C297 T298 L315 Q316 T317 I318
Binding residue
(residue number reindexed from 1)		S32 P33 Y226 R246 S248 C249 T250 L267 Q268 T269 I270
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:3plf, PDBe:3plf, PDBj:3plf
PDBsum3plf
PubMed21163258
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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