Structure of PDB 3omx Chain D Binding Site BS01

Receptor Information

>3omx Chain D (length=190) Species: 7227 (Drosophila melanogaster)

KLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNV
YEFGTKYEDIYRDLESKDKEFYTQNGLLHMLDRNRRIKKCPERFQDTKEQ
FDIIVTVEERVYDLVVMHMESMESVDNRPVHVLNVDVVDNAEDALMGAFV
ITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY

Ligand information

• Ligand ID: VO4
• InChI: InChI=1S/4O.V/q;3*-1;
• InChIKey: LSGOVYNHVSXFFJ-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341: [O-][V]([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-][V](=O)([O-])[O-]
• Formula: O4 V
• Name: VANADATE ION
• PDB chain: 3omx Chain D Residue 300

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3omx Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue.
• Resolution: 2.3366 Å
• Binding residue (original residue number in PDB): C13 S14 S15 M17 N18 R19 D144
• Binding residue (residue number reindexed from 1): C8 S9 S10 M12 N13 R14 D139
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.16: protein-serine/threonine phosphatase.

Gene Ontology

Molecular Function

• GO:0004721 phosphoprotein phosphatase activity
• GO:0004722 protein serine/threonine phosphatase activity
• GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity
• GO:0016791 phosphatase activity
• GO:0017018 myosin phosphatase activity

Biological Process

• GO:0006357 regulation of transcription by RNA polymerase II
• GO:0006369 termination of RNA polymerase II transcription
• GO:0006397 mRNA processing
• GO:0031124 mRNA 3'-end processing

Cellular Component

• GO:0005634 nucleus
• GO:0005847 mRNA cleavage and polyadenylation specificity factor complex

External links

• PDB: RCSB:3omx, PDBe:3omx, PDBj:3omx
• PDBsum: 3omx
• PubMed: 21204787
• UniProt: Q9VWE4