Structure of PDB 3n95 Chain D Binding Site BS01

Receptor Information

>3n95 Chain D (length=463) Species: 9606,83333

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFAALLHSLLEANCSLALAEELLLDGYSYC
NTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWA
SKINYSQCEPILD

Ligand information

>3n95 Chain F (length=16) Species: 9606 (Homo sapiens)

AAREQATTNARILARV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3n95 Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
• Resolution: 2.72 Å
• Binding residue (original residue number in PDB): P-322 Q-321 A-318 S-297 I47 F68 N69 Y73 K92 I93 Y95
• Binding residue (residue number reindexed from 1): P48 Q49 A52 S73 I407 F428 N429 Y433 K452 I453 Y455

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0015144 carbohydrate transmembrane transporter activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0008643 carbohydrate transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3n95, PDBe:3n95, PDBj:3n95
• PDBsum: 3n95
• UniProt: P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
  Q13324|CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (Gene Name=CRHR2)