Structure of PDB 3n07 Chain D Binding Site BS01

Receptor Information

>3n07 Chain D (length=177) Species: 666 (Vibrio cholerae)

STVSTLYGEVEPSLLEIAKQIKLLICDVDGVFSDGLIYMGNQGEELKTFH
TRDGYGVKALMNAGIEIAIITGRRSQIVENRMKALGISLIYQGQDDKVQA
YYDICQKLAIAPEQTGYIGDDLIDWPVMEKVALRVCVADGHPLLAQRANY
VTHIKGGHGAVREVCDLILQARNELDV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3n07 Chain D Residue 200

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3n07 Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis.
• Resolution: 1.76 Å
• Binding residue (original residue number in PDB): D29 D31 D122
• Binding residue (residue number reindexed from 1): D27 D29 D120
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.45: 3-deoxy-manno-octulosonate-8-phosphatase.

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0016787 hydrolase activity
• GO:0016788 hydrolase activity, acting on ester bonds
• GO:0019143 3-deoxy-manno-octulosonate-8-phosphatase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0008150 biological_process
• GO:0009103 lipopolysaccharide biosynthetic process

Cellular Component

• GO:0005575 cellular_component

External links

• PDB: RCSB:3n07, PDBe:3n07, PDBj:3n07
• PDBsum: 3n07
• PubMed: 23848398
• UniProt: Q9KP52