Structure of PDB 3m5n Chain D Binding Site BS01

Receptor Information
>3m5n Chain D (length=198) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEG
EVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKD
LVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRP
ISYLKGSAGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3m5n Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		H1057 R1123 L1135 G1137 A1139 F1154 R1155 A1156 A1157 V1158 S1159
Binding residue
(residue number reindexed from 1)		H76 R142 L154 G156 A158 F173 R174 A175 A176 V177 S178
Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 A1139
Catalytic site (residue number reindexed from 1) H76 D100 G156 A158
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3m5n, PDBe:3m5n, PDBj:3m5n
PDBsum3m5n
PubMed21084633
UniProtA8DG50

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