Structure of PDB 3lzb Chain D Binding Site BS01

Receptor Information
>3lzb Chain D (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKAN
KEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHK
DNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDF
GLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE
ISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMA
RDPQRYLVIQG
Ligand information
Receptor-Ligand Complex Structure
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PDB3lzb Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R681 W707 Q767
Binding residue
(residue number reindexed from 1)		R3 W29 Q85
Enzymatic activity
Catalytic site (original residue number in PDB) D813 A815 R817 N818 D831
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3lzb, PDBe:3lzb, PDBj:3lzb
PDBsum3lzb
PubMed20346655
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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