Structure of PDB 3k70 Chain D Binding Site BS01

Receptor Information
>3k70 Chain D (length=547) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGH
VCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPM
ILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDE
INWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIR
LAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPQR
LRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLA
SVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSL
CLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGE
DYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVA
GLNERIEQFMQQKRPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTP
VVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSS
Ligand information
>3k70 Chain X (length=46) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuuuuaucuaatgcgagcactgctatagcagtgctcgcatuagaua
Receptor-Ligand Complex Structure
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PDB3k70 DNA binding to RecD: role of the 1B domain in SF1B helicase activity.
Resolution3.59 Å
Binding residue
(original residue number in PDB)		P204 T205 T239 H241 A246 Q247 P248 Q251 I274 D275 M278
Binding residue
(residue number reindexed from 1)		P204 T205 T239 H241 A246 Q247 P248 Q249 I272 D273 M276
Enzymatic activity
Enzyme Commision number 5.6.2.3: DNA 5'-3' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0008854 exodeoxyribonuclease V activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 DNA damage response
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0009338 exodeoxyribonuclease V complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3k70, PDBe:3k70, PDBj:3k70
PDBsum3k70
PubMed18668125
UniProtP04993|RECD_ECOLI RecBCD enzyme subunit RecD (Gene Name=recD)

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