Structure of PDB 3ig6 Chain D Binding Site BS01

Receptor Information
>3ig6 Chain D (length=243) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIGGEFTTIENQPWFAAIYRRHSVTYVCGGSLISPCWVISATHCFIDYPK
KEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI
RSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQ
LKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLV
CSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
Ligand information
Receptor-Ligand Complex Structure
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PDB3ig6 Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA)
Resolution1.83 Å
Binding residue
(original residue number in PDB)		N26 W29 P49 A112 Q113 P114 R116 Q119 T120 C122 R206 M207
Binding residue
(residue number reindexed from 1)		N11 W14 P35 A108 Q109 P110 R112 Q115 T116 C118 R206 M207
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D94 Q192 G193 D194 S195 G196
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ig6, PDBe:3ig6, PDBj:3ig6
PDBsum3ig6
PubMed19703768
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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