Structure of PDB 3iec Chain D Binding Site BS01

Receptor Information

>3iec Chain D (length=311) Species: 9606 (Homo sapiens)

HIGNYRLLKTIGAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR
IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGWMKEKEA
RAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTF
GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG
QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDR
WMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYN
EVMATYLLLGY

Ligand information

>3iec Chain H (length=14) Species: 210 (Helicobacter pylori)

FPLKRHDKVDDLSK

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3iec Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): E136 F138 D139 D175 E179 D193 F196 F209 C210 G211 P214 F221 S247 L248 P249 D251 K256 R261
• Binding residue (residue number reindexed from 1): E84 F86 D87 D123 E127 D141 F144 F157 C158 G159 P162 F169 S195 L196 P197 D199 K204 R209

Enzymatic activity

• Catalytic site (original residue number in PDB): D175 K177 E179 N180 D193 S212
• Catalytic site (residue number reindexed from 1): D123 K125 E127 N128 D141 S160
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.11.26: [tau protein] kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:3iec, PDBe:3iec, PDBj:3iec
• PDBsum: 3iec
• PubMed: 19966800
• UniProt: Q7KZI7|MARK2_HUMAN Serine/threonine-protein kinase MARK2 (Gene Name=MARK2)