Structure of PDB 3hw6 Chain D Binding Site BS01

Receptor Information
>3hw6 Chain D (length=175) Species: 93838 (Influenza A virus (A/goose/Guangdong/1/1996(H5N1))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFM
YSRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGV
TRREVHTYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIK
TRLFTIRQEMASRGLWDSFRQSERG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3hw6 Chain D Residue 257 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3hw6 Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H41 D108 E119 I120
Binding residue
(residue number reindexed from 1)		H44 D86 E97 I98
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3hw6, PDBe:3hw6, PDBj:3hw6
PDBsum3hw6
PubMed19587036
UniProtQ9Q0U9|PA_I96A0 Polymerase acidic protein (Gene Name=PA)

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