Structure of PDB 3hb1 Chain D Binding Site BS01

Receptor Information
>3hb1 Chain D (length=256) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLAD
THLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHGGVDWMRKLAF
RYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKAL
NLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKES
CFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHA
LELEYL
Ligand information
Ligand IDAF3
InChIInChI=1S/Al.3FH/h;3*1H/q+3;;;/p-3
InChIKeyKLZUFWVZNOTSEM-UHFFFAOYSA-K
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al](F)F
FormulaAl F3
NameALUMINUM FLUORIDE
ChEMBL
DrugBank
ZINC
PDB chain3hb1 Chain D Residue 804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3hb1 Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor
Resolution2.51 Å
Binding residue
(original residue number in PDB)		D274 L275 D276 T447 T448 K480
Binding residue
(residue number reindexed from 1)		D7 L8 D9 T165 T166 K198
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0007275 multicellular organism development

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Molecular Function
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Biological Process
External links
PDB RCSB:3hb1, PDBe:3hb1, PDBj:3hb1
PDBsum3hb1
PubMed19858093
UniProtO00167|EYA2_HUMAN Eyes absent homolog 2 (Gene Name=EYA2)

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