Structure of PDB 3fm8 Chain D Binding Site BS01

Receptor Information
>3fm8 Chain D (length=353) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQV
SKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLL
REQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLT
EREGALKYFNREPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNI
FIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDADLVPKLSRNYLKEGY
MEKTGPFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFP
PSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQE
YAV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3fm8 Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3fm8 Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C21 C24 C41 C44
Binding residue
(residue number reindexed from 1)		C17 C20 C37 C40
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding
GO:0046872 metal ion binding
GO:1902936 phosphatidylinositol bisphosphate binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fm8, PDBe:3fm8, PDBj:3fm8
PDBsum3fm8
PubMed21057110
UniProtO75689|ADAP1_HUMAN Arf-GAP with dual PH domain-containing protein 1 (Gene Name=ADAP1)

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