Structure of PDB 3f9w Chain D Binding Site BS01

Receptor Information
>3f9w Chain D (length=161) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDF
VVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETN
RLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLFDYGDRSK
ASIEAHPWLKH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3f9w Structural origins for the product specificity of SET domain protein methyltransferases.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		Y245 E259 Y262 C270 M272 Y273 Y274 T307 Y336 G337 D338 R339 S343 H347 W349
Binding residue
(residue number reindexed from 1)		Y54 E68 Y71 C79 M81 Y82 Y83 T116 Y145 G146 D147 R148 S152 H156 W158
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3f9w, PDBe:3f9w, PDBj:3f9w
PDBsum3f9w
PubMed19088188
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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