Structure of PDB 3d23 Chain D Binding Site BS01

Receptor Information
>3d23 Chain D (length=299) Species: 443239 (Human coronavirus HKU1 (isolate N1)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGIVKMVSPTSKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICSSSNMN
EPDYSALLCRVTLGDFTIMSGRMSLTVVSYQMQGCQLVLTVSLQNPYTPK
YTFGNVKPGETFTVLAAYNGRPQGAFHVTMRSSYTIKGSFLCGSCGSVGY
VLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQVVQLPVKDYVQ
TVNVIAWLYAAILNNCAWFVQNDVCSTEDFNVWAMANGFSQVKADLVLDA
LASMTGVSIETLLAAIKRLYMGFQGRQILGSCTFEDELAPSDVYQQLAG
Ligand information
Receptor-Ligand Complex Structure
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PDB3d23 Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		F140 C142 G143 C145 H163 Q164 L165 E166 Q189 V190 V191
Binding residue
(residue number reindexed from 1)		F140 C142 G143 C145 H163 Q164 L165 E166 Q189 V190 V191
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G143 C145
Catalytic site (residue number reindexed from 1) H41 G143 C145
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:3d23, PDBe:3d23, PDBj:3d23
PDBsum3d23
PubMed18562531
UniProtP0C6U3|R1A_CVHN1 Replicase polyprotein 1a (Gene Name=1a)

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