Structure of PDB 3aoh Chain D Binding Site BS01

Receptor Information
>3aoh Chain D (length=1349) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFG
PIKDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAH
IWFVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQ
LLTDEEYRELRYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG
VALYRFPRRVRVEYVTEPKDYRVQPHMNVVVPEGARVEAGDKIVAAIDPE
EEVIAEAEGVVHLHEPASILVVKARVYPFEDDVEVSTGDRVAPGDVLADG
GKVKSDVYGRVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEALE
KELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDL
RPSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDALLDNG
RRGAPVTNPGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGP
QLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRDIKD
EVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEA
FNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDI
ILGLYYITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRETS
VGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILFARI
VAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALK
YYGFTFSTTSGITIGIDDAVIPEEKKQYLEEADRKLLQIEQAYEMGFLTD
RERYDQILQLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQQI
RQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGADTA
LRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRSLRLR
KRADIEAGLYGRVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQE
VPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQ
LTTQGLPRVIELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESEGFS
KEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVE
EIQKVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDV
EALNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEA
AIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEAR
Ligand information
Receptor-Ligand Complex Structure
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PDB3aoh Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein
Resolution4.1 Å
Binding residue
(original residue number in PDB)		R628 P706 S1091
Binding residue
(residue number reindexed from 1)		R493 P571 S956
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3aoh, PDBe:3aoh, PDBj:3aoh
PDBsum3aoh
PubMed21124318
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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