Structure of PDB 3al5 Chain D Binding Site BS01

Receptor Information
>3al5 Chain D (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVG
GKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDE
KYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSP
GLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNP
DLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHL
PSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVL
HIQDKAYS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3al5 Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3al5 Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.
Resolution2.503 Å
Binding residue
(original residue number in PDB)		H160 H235
Binding residue
(residue number reindexed from 1)		H157 H232
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.42: tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0102524 tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity
Biological Process
GO:0008033 tRNA processing
GO:0031591 wybutosine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3al5, PDBe:3al5, PDBj:3al5
PDBsum3al5
PubMed20972222
UniProtA2RUC4|TYW5_HUMAN tRNA wybutosine-synthesizing protein 5 (Gene Name=TYW5)

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