Structure of PDB 2yzb Chain D Binding Site BS01

Receptor Information

>2yzb Chain D (length=287) Species: 1665 (Arthrobacter globiformis)

TKVVLGQNQYGKAEVRLVKVTRNTARHEIQDLNVTSQLRGDFEAAHTAGD
NAHVVATDTQKNTVYAFARDGFATTEEFLLRLGKHFTEGFDWVTGGRWAA
QQFFWDRINDHDHAFSRNKSEVRTAVLEISGSEQAIVAGIEGLTVLKSTG
SEFHGFPRDKYTTLQETTDRILATDVSARWRYNTVEVDFDAVYASVRGLL
LKAFAETHSLALQQTMYEMGRAVIETHPEIDEIKMSLPNKHHFLVDLQPF
GQDNPNEVFYAADRPYGLIEATIQREGSRADHPIWSN

Ligand information

• Ligand ID: URC
• InChI: InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
• InChIKey: LEHOTFFKMJEONL-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: O=C1NC(=O)C2=C(N1)NC(=O)N2
  OpenEye OEToolkits 1.5.0: C12=C(NC(=O)N1)NC(=O)NC2=O
  ACDLabs 10.04: O=C1C2=C(NC(=O)N1)NC(=O)N2
• Formula: C5 H4 N4 O3
• Name: URIC ACID;
  7,9-DIHYDRO-1H-PURINE-2,6,8(3H)-TRIONE
• ChEMBL: CHEMBL792
• DrugBank: DB08844
• ZINC: ZINC000002041003
• PDB chain: 2yzb Chain A Residue 2304

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2yzb Trapping of the uric acid substrate in the crystal structure of urate oxidase from Arthrobacter globiformis
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): F163 R180 A221 L222 Q223
• Binding residue (residue number reindexed from 1): F153 R170 A211 L212 Q213
• Annotation score: 5

Enzymatic activity

• Catalytic site (original residue number in PDB): K22 T67 R180 Q223 H251
• Catalytic site (residue number reindexed from 1): K12 T57 R170 Q213 H241
• Enzyme Commision number: 1.7.3.3: factor independent urate hydroxylase.

Gene Ontology

Molecular Function

• GO:0004846 urate oxidase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0019628 urate catabolic process

External links

• PDB: RCSB:2yzb, PDBe:2yzb, PDBj:2yzb
• PDBsum: 2yzb
• UniProt: D0VWQ1|URIC_ARTGO Uricase (Gene Name=uox)