Structure of PDB 2x6s Chain D Binding Site BS01

Receptor Information
>2x6s Chain D (length=175) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKPFDKFFMDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTKAPSTSATVK
SLNVLTSIAIPRVIHSDQGAAFTSSTFAEWAKERGIHLEFSVERKNSDMK
RLLTKLLVGRPTKWYDLLPVVQLAMNNTYSPVLKYTPHQLLFGIDSNTPF
ANQDTLDLTREEELSLLQEIRTSLY
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2x6s Chain D Residue 1304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2x6s Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase
Resolution2.29 Å
Binding residue
(original residue number in PDB)		D128 D185
Binding residue
(residue number reindexed from 1)		D10 D67
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:2x6s, PDBe:2x6s, PDBj:2x6s
PDBsum2x6s
PubMed20693659
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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