Structure of PDB 2x2f Chain D Binding Site BS01

Receptor Information
>2x2f Chain D (length=333) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFSMEDLIPLVNRLQDAFSADLDLPQIAVVGGQSAGKSSVLENFVGRDFL
PRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDR
VTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIR
DMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKL
DLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERK
FFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSI
EKEVEEYKNFSRVDEMLRMYHALKEALSIIGNI
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain2x2f Chain D Residue 1746 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2x2f G Domain Dimerization Controls Dynamin'S Assembly-Stimulated Gtpase Activity.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S41 G43 K44 S45 S46 R59 G60 K206 D208 L209 V235 N236 R237 S238 Q239
Binding residue
(residue number reindexed from 1)		S34 G36 K37 S38 S39 R52 G53 K199 D201 L202 V228 N229 R230 S231 Q232
Annotation score4
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2x2f, PDBe:2x2f, PDBj:2x2f
PDBsum2x2f
PubMed20428113
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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