Structure of PDB 2wv5 Chain D Binding Site BS01

Receptor Information

>2wv5 Chain D (length=200) Species: 12112 (Foot-and-mouth disease virus (strain A10-61))

DLQKMVMGNTKPVELILDGKTVAICCATGVFGTAYLVPRHLFAEKYDKIM
LDGRAMTDSDYRVFEFEIKVKGQDMLSDAALMVLHRGNKVRDITKHFRDT
ARMKKGTPVVGVVNNADVGRLIFSGEALTYKDIVVLMDGDTMPGLFAYKA
ATRAGYAGGAVLAKDGADTFIVGTHSAGGNGVGYCSCVSRSMLQKMKAHV

Ligand information

>2wv5 Chain H (length=9) Species: 12112 (Foot-and-mouth disease virus (strain A10-61))

APAKELLNF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wv5 Insights Into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): V28 A29 I30 H46 E50 L142 M143 D144 D146 T158 R159 A160 G161 A163 H181 S182 A183 G184 N186 Y190
• Binding residue (residue number reindexed from 1): V22 A23 I24 H40 E44 L136 M137 D138 D140 T152 R153 A154 G155 A157 H175 S176 A177 G178 N180 Y184

Enzymatic activity

• Catalytic site (original residue number in PDB): H46 D84 A163 S182
• Catalytic site (residue number reindexed from 1): H40 D78 A157 S176
• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0004197 cysteine-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:2wv5, PDBe:2wv5, PDBj:2wv5
• PDBsum: 2wv5
• PubMed: 19883658
• UniProt: P03306|POLG_FMDV1 Genome polyprotein