Structure of PDB 2waq Chain D Binding Site BS01

Receptor Information
>2waq Chain D (length=260) Species: 2286 (Saccharolobus shibatae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SINLLHKDDKRIDLVFEGYPLEFVNAIRRAAMLYVPVMSIDDVYFIENNS
PLYDEILAHRLALIPFTSEEALDTYRWPEECIDCCEKCYTKIYIEAEALN
EPKMLYSKDIKSEDPSIVPISGDIPIVLLGANQKISLEARLRLGYGKEHA
KFIPVSLAIVRYYPKVEILGNCEKGATVCPEGVFELKDGKLSVKNELACT
LCEECLRYCNGLIRISSVEDKYILELESVGSLKPERILLEAGKSIIRKIE
ELEKKLVEVI
Ligand information
Ligand IDF3S
InChIInChI=1S/3Fe.4S
InChIKeyFCXHZBQOKRZXKS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385S1[Fe]S[Fe]2S[Fe]1S2
OpenEye OEToolkits 2.0.7S1[Fe]2S[Fe]3[S]2[Fe]1S3
FormulaFe3 S4
NameFE3-S4 CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain2waq Chain D Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2waq Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		C183 V187 F188 C203 C206 E207 C209 I219
Binding residue
(residue number reindexed from 1)		C179 V183 F184 C199 C202 E203 C205 I215
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
GO:0051536 iron-sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2waq, PDBe:2waq, PDBj:2waq
PDBsum2waq
PubMed19419240
UniProtB8YB56|RPO3_SACSH DNA-directed RNA polymerase subunit Rpo3 (Gene Name=rpo3)

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