Structure of PDB 2vnu Chain D Binding Site BS01

Receptor Information
>2vnu Chain D (length=694) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLI
VGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDIQPTAKVVYIQ
RRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLD
KRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFS
KKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPG
CVDINDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYL
VDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVI
RSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNL
ASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAF
PQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDP
EDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPI
RRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGR
ASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTE
DPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRKRKAEL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2vnu Structure of the Active Subunit of the Yeast Exosome Core, Rrp44: Diverse Modes of Substrate Recruitment in the Rnase II Nuclease Family
Resolution2.3 Å
Binding residue
(original residue number in PDB)
N277 Q279 S291 D543 P544 C547 D549 N551 D552 Y595 Y654 L696 A697 E700 E728 M731 R753 H755 M813 M814 A815 A816 H831 L834 Y839 H841 T843 R847 R896
Binding residue
(residue number reindexed from 1)
N26 Q28 S40 D247 P248 C251 D253 N255 D256 Y299 Y358 L400 A401 E404 E432 M435 R457 H459 M517 M518 A519 A520 H535 L538 Y543 H545 T547 R551 R600
Enzymatic activity
Catalytic site (original residue number in PDB) D543 D549 N551 D552
Catalytic site (residue number reindexed from 1) D247 D253 N255 D256
Enzyme Commision number 3.1.13.-
3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2vnu, PDBe:2vnu, PDBj:2vnu
PDBsum2vnu
PubMed18374646
UniProtQ08162|RRP44_YEAST Exosome complex exonuclease DIS3 (Gene Name=DIS3)

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