Structure of PDB 2v0g Chain D Binding Site BS01

Receptor Information
>2v0g Chain D (length=876) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVMFPYPSGDLHM
GHLKNYTMGDVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDW
TYANIRQAKESLRLMGILYDWDREVTTCEPEYYRWNQWIFLKMWEKGLAY
RAKGLVNWCPKCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYA
ERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKEVRIPVFTTRP
DTLFGATFLVLAPEHPLTLELAAPEKREEVLAYVEAAKRKTEIERQAEGR
EKTGVFLGAYALNPATGERIPIWTADYVLFGYGTGAIMAVPAHDQRDYEF
ARKFGLPIKKVIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRK
VIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCEACGVVPVPEE
ELPVLLPDLKDVEDIRPKGKSPLEAHPEFYETTCPKCGGPAKRDTDTMDT
FFDSSWYYLRYTDPHNDRLPFDPEKANAWMPVDQYIGGVEHAVLHLLYSR
FFTKFLHDLGMVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTR
IRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSKSKGNGVMVGP
FVKEQGADIARITILFAAPPENEMVWTEEGVQGAWRFLNRIYRRVAEDRE
ALLETSGVFQAEALEGKDRELYGKLHETLKKVTEDLEALRFNTAIAALME
FLNALYEYRKDRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLF
EAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLEVARAEALKVR
NVRAHLEGKEVVKEIYVPGKILNLVV
Ligand information
>2v0g Chain F (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccgggguggcggaagguagacgcgcaugacaucaugugcgcaagcgugc
ggguucaagucccgcccccggcacca
<<<<<<<..<<<.........>>><<<<<<..>>>>>><<....>>..<<
<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB2v0g An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		V172 E214 K215 S227 F246 T247 T248 R249 K302 Y327 V328 L329 Y332 I337 H343 D344 R346 R418 F666 P669 N672 E679 R686 E750 A820 Q822 V827 N873
Binding residue
(residue number reindexed from 1)		V172 E214 K215 S227 F246 T247 T248 R249 K302 Y327 V328 L329 Y332 I337 H343 D344 R346 R418 F666 P669 N672 E679 R686 E750 A820 Q822 V827 N873
Enzymatic activity
Catalytic site (original residue number in PDB) F501 H541 F551 V637 K640
Catalytic site (residue number reindexed from 1) F501 H541 F551 V637 K640
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2v0g, PDBe:2v0g, PDBj:2v0g
PDBsum2v0g
PubMed17588934
UniProtQ7SIE4

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