Structure of PDB 2uue Chain D Binding Site BS01

Receptor Information
>2uue Chain D (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE
YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPE
VAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQP
ANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLL
NPPETLNL
Ligand information
Receptor-Ligand Complex Structure
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PDB2uue Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors
Resolution2.06 Å
Binding residue
(original residue number in PDB)		M210 I213 L214 W217 R250 Q254 T282 D283 T285
Binding residue
(residue number reindexed from 1)		M36 I39 L40 W43 R76 Q80 T108 D109 T111
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0044772 mitotic cell cycle phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:2uue, PDBe:2uue, PDBj:2uue
PDBsum2uue
PubMed17051658
UniProtP20248|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

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