Structure of PDB 2qki Chain D Binding Site BS01

Receptor Information
>2qki Chain D (length=632) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSE
KTVLTPATNHMGNVTFTIPSEKGRNKFVTVQATFGTQVVEKVVLVSLQSG
YLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQD
SLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYV
LPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDG
EQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNLRAEDLVGKSLYVSA
TVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTN
PDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKK
QELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLR
MDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPS
FRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQPVPGQQMTL
KIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGK
DYAGVFSDAGLTFTSSSGQQTAQRAELQCPQP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2qki Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		G345 P347 N390 T391 L454 L455 R456 M457 R459 E462 R486 D491 L492
Binding residue
(residue number reindexed from 1)		G339 P341 N384 T385 L448 L449 R450 M451 R453 E456 R480 D485 L486
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004866 endopeptidase inhibitor activity

View graph for
Molecular Function
External links
PDB RCSB:2qki, PDBe:2qki, PDBj:2qki
PDBsum2qki
PubMed17684013
UniProtP01024|CO3_HUMAN Complement C3 (Gene Name=C3)

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