Structure of PDB 2pa8 Chain D Binding Site BS01

Receptor Information
>2pa8 Chain D (length=264) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SINLLHKDDTRIDLVFEGYPLEFVNAIRRASMLYVPIMAVDDVYFIENNS
PLYDEILAHRLALIPFMSEEALDTYRWPEECIECTENCEKCYTKIYIEAE
APNEPRMIYSKDIKSEDPSVVPISGDIPIVLLGTNQKISLEARLRLGYGK
EHAKFIPVSLSVVRYYPKVEILANCEKAVNVCPEGVFELKDGKLSVKNEL
SCTLCEECLRYCNGSIRISFVEDKYILEIESVGSLKPERILLEAGKSIIR
KIEELEKKLVEVVK
Ligand information
Ligand IDF3S
InChIInChI=1S/3Fe.4S
InChIKeyFCXHZBQOKRZXKS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385S1[Fe]S[Fe]2S[Fe]1S2
OpenEye OEToolkits 2.0.7S1[Fe]2S[Fe]3[S]2[Fe]1S3
FormulaFe3 S4
NameFE3-S4 CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain2pa8 Chain D Residue 3076 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2pa8 The X-ray crystal structure of RNA polymerase from Archaea.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		C183 V187 F188 C203 T204 L205 C206 E207 C209 I219
Binding residue
(residue number reindexed from 1)		C182 V186 F187 C202 T203 L204 C205 E206 C208 I218
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
GO:0051536 iron-sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pa8, PDBe:2pa8, PDBj:2pa8
PDBsum2pa8
PubMed18235446
UniProtP95989|RPO3_SACS2 DNA-directed RNA polymerase subunit Rpo3 (Gene Name=rpo3)

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