Structure of PDB 2hse Chain D Binding Site BS01

Receptor Information

>2hse Chain D (length=146) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QVEAIKRGTVIDHIPAQIGFKLLSLFKLTETDQRITIGLNLPSGEMGRKD
LIKIENTFLSEDQVDQLALYAPQATVNRIDNYEVVGKSRPSLPERIDNVL
VCPNSNCISHAEPVSSSFAVRKRANDIALKCKYCEKEFSHNVVLAN

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

2hse Chain D Residue 955 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	2hse The allosteric transition induced by the aspartate binding to Aspartate Transcarbamoylase
Resolution	2.6 Å
Binding residue (original residue number in PDB)	C109 C114 C138 C141
Binding residue (residue number reindexed from 1)	C102 C107 C131 C134
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221	pyrimidine nucleotide biosynthetic process

	Cellular Component
GO:0005737	cytoplasm
GO:0009347	aspartate carbamoyltransferase complex

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Cellular Component

External links

PDB	RCSB:2hse, PDBe:2hse, PDBj:2hse
PDBsum	2hse
PubMed
UniProt	P0A7F3\|PYRI_ECOLI Aspartate carbamoyltransferase regulatory chain (Gene Name=pyrI)

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