BioLiP

Receptor Information

>2gl7 Chain D (length=506) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVS
AIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS
PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAI
TTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKV
LSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQE
GMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEA
LVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVK
LLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD
TQRFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP
IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAA
AVLFRM

>2gl7 Chain E (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

LGANDELISFKDEGEQEDLADVKSSLVN

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2gl7 Crystal Structure of a beta-Catenin/BCL9/Tcf4 Complex.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	F253 N261 K292 D299 Q302 Y306 K312 K335 W338 V346 V349 R386 N387 N426 C429 N430 K435 H470 R474 K508 G512 N516
Binding residue (residue number reindexed from 1)	F107 N115 K146 D153 Q156 Y160 K166 K189 W192 V200 V203 R240 N241 N280 C283 N284 K289 H324 R328 K362 G366 N370

Enzyme Commision number

	Molecular Function
GO:0045296	cadherin binding

	Biological Process
GO:0007155	cell adhesion

PDB	RCSB:2gl7, PDBe:2gl7, PDBj:2gl7
PDBsum	2gl7
PubMed	17052462
UniProt	P35222\|CTNB1_HUMAN Catenin beta-1 (Gene Name=CTNNB1)

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Structure of PDB 2gl7 Chain D Binding Site BS01