Structure of PDB 2g9t Chain D Binding Site BS01

Receptor Information
>2g9t Chain D (length=118) Species: 694009 (Severe acute respiratory syndrome-related coronavirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVT
PEANMDQESFGGASCCLYCRCHIDHPNFCDLKGKYVQIPTTCANDPVGFT
LRNTVCTVCGMWKGYGCS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2g9t Chain D Residue 998 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2g9t Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10
Resolution2.1 Å
Binding residue
(original residue number in PDB)		C74 C77 H83 C90
Binding residue
(residue number reindexed from 1)		C66 C69 H75 C79
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008270 zinc ion binding
Biological Process
GO:0019079 viral genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2g9t, PDBe:2g9t, PDBj:2g9t
PDBsum2g9t
PubMed16873247
UniProtP0C6U8|R1A_SARS Replicase polyprotein 1a (Gene Name=1a)

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