Structure of PDB 2bte Chain D Binding Site BS01

Receptor Information
>2bte Chain D (length=876) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVMFPYPSGDLHM
GHLKNYTMGDVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDW
TYANIRQAKESLRLMGILYDWDREVTTCEPEYYRWNQWIFLKMWEKGLAY
RAKGLVNWCPKCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYA
ERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKEVRIPVFTTRP
DTLFGATFLVLAPEHPLTLELAAPEKREEVLAYVEAAKRKTEIERQAEGR
EKTGVFLGAYALNPATGERIPIWTADYVLFGYGTGAIMAVPAHDQRDYEF
ARKFGLPIKKVIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRK
VIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCEACGVVPVPEE
ELPVLLPDLKDVEDIRPKGKSPLEAHPEFYETTCPKCGGPAKRDTDTMDT
FFDSSWYYLRYTDPHNDRLPFDPEKANAWMPVDQYIGGVEHAVLHLLYSR
FFTKFLHDLGMVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTR
IRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSKSKGNGVMVGP
FVKEQGADIARITILFAAPPENEMVWTEEGVQGAWRFLNRIYRRVAEDRE
ALLETSGVFQAEALEGKDRELYGKLHETLKKVTEDLEALRFNTAIAALME
FLNALYEYRKDRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLF
EAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLEVARAEALKVR
NVRAHLEGKEVVKEIYVPGKILNLVV
Ligand information
>2bte Chain E (length=78) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccgggguggcggaauggguagacgcgcaugacaucaugugcgcaagcgu
gcggguucaagucccgcccccggcacca
<<<<<<<..<<<...........>>><<<<<<..>>>>>><<....>>..
<<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB2bte The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer- Editing Conformation.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E214 K215 M219 A222 G225 S227 T248 P380 K398 R418 F666 P669 E679 R686 A746 M749 E750 E818 A820 N824 R826 I865 V867 K870 I871 N873 V875
Binding residue
(residue number reindexed from 1)		E214 K215 M219 A222 G225 S227 T248 P380 K398 R418 F666 P669 E679 R686 A746 M749 E750 E818 A820 N824 R826 I865 V867 K870 I871 N873 V875
Enzymatic activity
Catalytic site (original residue number in PDB) F501 H541 F551 V637 K640
Catalytic site (residue number reindexed from 1) F501 H541 F551 V637 K640
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2bte, PDBe:2bte, PDBj:2bte
PDBsum2bte
PubMed16155583
UniProtQ7SIE4

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