Structure of PDB 2az1 Chain D Binding Site BS01

Receptor Information

>2az1 Chain D (length=155) Species: 2242 (Halobacterium salinarum)

HDERTFVMVKPDGVQRGLIGDIVTRLETKGLKMVGGKFMRIDEELAHEHY
AEHEDKPFFDGLVSFITSGPVFAMVWEGADATRQVRQLMGATDAQDAAPG
TIRGDYGNDLGHNLIHGSDHEDEGANEREIALFFDDDELVDWDRDASAWV
YEDLA

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2az1 Chain D Residue 202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2az1 Structure of a halophilic nucleoside diphosphate kinase from Halobacterium salinarum
• Resolution: 2.35 Å
• Binding residue (original residue number in PDB): A134 F137 D138
• Binding residue (residue number reindexed from 1): A131 F134 D135
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): K13 H52 Y53 N116 H119 E132
• Catalytic site (residue number reindexed from 1): K10 H49 Y50 N113 H116 E129
• Enzyme Commision number: 2.7.4.6: nucleoside-diphosphate kinase.

Gene Ontology

Molecular Function

• GO:0004550 nucleoside diphosphate kinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006183 GTP biosynthetic process
• GO:0006228 UTP biosynthetic process
• GO:0006241 CTP biosynthetic process
• GO:0009117 nucleotide metabolic process
• GO:0016310 phosphorylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2az1, PDBe:2az1, PDBj:2az1
• PDBsum: 2az1
• PubMed: 16293253
• UniProt: P61136|NDK_HALSA Nucleoside diphosphate kinase (Gene Name=ndk)