Structure of PDB 1tt5 Chain D Binding Site BS01

Receptor Information
>1tt5 Chain D (length=395) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKN
LALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVP
NCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYED
GVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMC
TIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLE
RASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYI
PLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQLQEVLDYLTNSA
SLQMKSPAITATKNRTLYLQVTSIEERTRPLAVADVTTPQTVLFK
Ligand information
Receptor-Ligand Complex Structure
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PDB1tt5 A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H32 F44 R136 Q137 F138 H139 P176 L193 I310
Binding residue
(residue number reindexed from 1)		H16 F28 R120 Q121 F122 H123 P160 L177 I294
Enzymatic activity
Catalytic site (original residue number in PDB) K21 D146 C216 T217 A219
Catalytic site (residue number reindexed from 1) K5 D130 C200 T201 A203
Enzyme Commision number 6.2.1.64: E1 NEDD8-activating enzyme.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0016874 ligase activity
GO:0019781 NEDD8 activating enzyme activity
GO:0019788 NEDD8 transferase activity
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0006508 proteolysis
GO:0007113 endomitotic cell cycle
GO:0036211 protein modification process
GO:0043687 post-translational protein modification
GO:0045116 protein neddylation
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tt5, PDBe:1tt5, PDBj:1tt5
PDBsum1tt5
PubMed15361859
UniProtQ8TBC4|UBA3_HUMAN NEDD8-activating enzyme E1 catalytic subunit (Gene Name=UBA3)

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