Structure of PDB 1t2v Chain D Binding Site BS01

Receptor Information
>1t2v Chain D (length=205) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFV
CERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNH
QGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELS
SFTLGTGVHPIVVVQPDAWTFHAIGQMCAPVVTREWVLDSVALYQCQELD
TYLIP
Ligand information
Receptor-Ligand Complex Structure
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PDB1t2v Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S1655 P1659 E1698 R1699 T1700 K1702 N1774 M1775
Binding residue
(residue number reindexed from 1)		S9 P13 E52 R53 T54 K56 N128 M129
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1t2v, PDBe:1t2v, PDBj:1t2v
PDBsum1t2v
PubMed15133503
UniProtP38398|BRCA1_HUMAN Breast cancer type 1 susceptibility protein (Gene Name=BRCA1)

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