Structure of PDB 1szs Chain D Binding Site BS01

Receptor Information
>1szs Chain D (length=425) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSNKELMQRRSQAIPRGVGQIHPIFADRAENCRVWDVEGREYLDFAGGQA
VLNTGHLHPKVVAAVEAQLKKLSHTCFQVLAYEPYLELCEIMNQKVPGDF
AKKTLLVTTGSEAVENAVKIARAATKRSGTIAFSGAYHGRTHYTLALTGK
VNPYSAGMGLMPGHVYRALYPCPLHGISEDDAIASIHRIFKNDAAPEDIA
AIVIEPVQGEGGFYASSPAFMQRLRALCDEHGIMLIADEVQSGAGRTGTL
FAMEQMGVAPDLTTFAKSIAGGFPLAGVTGRAEVMDAVAPGGLGGTYAGN
PIACVAALEVLKVFEQENLLQKANDLGQKLKDGLLAIAEKHPEIGDVRGL
GAMIAIELFEDGDHNKPDAKLTAEIVARARDKGLILLSCGPYYNVLRILV
PLTIEDAQIRQGLEIISQCFDEAKQ
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1szs Chain D Residue 1264 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1szs Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coligamma-Aminobutyrate Aminotransferase.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		G111 S112 Y138 H139 E206 D239 V241 Q242 K268
Binding residue
(residue number reindexed from 1)		G110 S111 Y137 H138 E205 D238 V240 Q241 K267
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) V19 Y138 E206 D239 Q242 K268 T297 R398
Catalytic site (residue number reindexed from 1) V18 Y137 E205 D238 Q241 K267 T296 R397
Enzyme Commision number 2.6.1.19: 4-aminobutyrate--2-oxoglutarate transaminase.
2.6.1.48: 5-aminovalerate transaminase.
Gene Ontology
Molecular Function
GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity
GO:0042803 protein homodimerization activity
GO:0047589 5-aminovalerate transaminase activity
Biological Process
GO:0009448 gamma-aminobutyric acid metabolic process
GO:0009450 gamma-aminobutyric acid catabolic process
GO:0042450 arginine biosynthetic process via ornithine
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1szs, PDBe:1szs, PDBj:1szs
PDBsum1szs
PubMed15723541
UniProtP22256|GABT_ECOLI 4-aminobutyrate aminotransferase GabT (Gene Name=gabT)

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