Structure of PDB 1s77 Chain D Binding Site BS01

Receptor Information
>1s77 Chain D (length=828) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMFERQLKA
GEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTAFQFLQEIKP
EAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKH
FKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGAWSSWHKEDSIHVGVRC
IEMLIESTGMVSLHSETIELAPEYAEAIATRAGALAGISPMFQPCVVPPK
PWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAINIAQNT
AWKINKKVLAVANVITKWKHCPVEDIPAIEREELPWKRAAAAVYRKDKAR
KSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDMTK
GLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHENIMA
CAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDGSCS
GIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAINGTD
NEVVKLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTI
QPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKL
LAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQF
RLQPTINTNKDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIE
SFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQLHE
SQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB1s77 The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Resolution2.69 Å
Binding residue
(original residue number in PDB)		R50 R57 K160 Y178 R298 K389 R423 Y427 R632 T636 G640 S641 F644 Y739 H772 S776 G777 P780
Binding residue
(residue number reindexed from 1)		R39 R46 K149 Y167 R272 K348 R382 Y386 R577 T581 G585 S586 F589 Y684 H717 S721 G722 P725
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s77, PDBe:1s77, PDBj:1s77
PDBsum1s77
PubMed15016374
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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