Structure of PDB 1pzy Chain D Binding Site BS01

Receptor Information

>1pzy Chain D (length=271) Species: 9913 (Bos taurus)

TACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHK
VAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKL
LNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFG
FSLPYVQYFGGVSALSKQQFLSINGFPNNYWGAGGEDDDIYNRLAFRGMS
VSRPNAVIGKTRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYM
VLEVQRYPLYTKITVDIGTPS

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 1pzy Chain D Residue 410

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1pzy The Role of Tryptophan 314 in the Conformational Changes of beta 1,4-Galactosyltransferase-I
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): D254 H347
• Binding residue (residue number reindexed from 1): D123 H216
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D252 D254 A314 E317 D318 M344 H347 R349
• Catalytic site (residue number reindexed from 1): D121 D123 A183 E186 D187 M213 H216 R218
• Enzyme Commision number: 2.4.1.-
  2.4.1.22: lactose synthase.
  2.4.1.275: neolactotriaosylceramide beta-1,4-galactosyltransferase.
  2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase.
  2.4.1.90: N-acetyllactosamine synthase.

Gene Ontology

Molecular Function

• GO:0016757 glycosyltransferase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:1pzy, PDBe:1pzy, PDBj:1pzy
• PDBsum: 1pzy
• PubMed: 12927542
• UniProt: P08037|B4GT1_BOVIN Beta-1,4-galactosyltransferase 1 (Gene Name=B4GALT1)