Structure of PDB 1orw Chain D Binding Site BS01

Receptor Information

>1orw Chain D (length=728) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SRRTYTLTDYLKSTFRVKFYTLQWISDHEYLYKQENNILLFNAEYGNSSI
FLENSTFDELGYSTNDYSVSPDRQFILFEYNYVKQWRHSYTASYDIYDLN
KRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNLSSQRITWT
GKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEY
SFYSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIV
PPASVLIGDHYLCGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWI
SSVARQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQ
TDKSNCTFITKGAWEVIGIEALTSDYLYYISNEHKGMPGGRNLYRIQLND
YTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLYTLHSSSSD
KELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSK
KYPLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGD
KIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSM
VLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDYYRNSTV
MSRAENFKQVEYLLIHGTADDNVHFQQSAQLSKALVDAGVDFQTMWYTDE
DHGIASNMAHQHIYTHMSHFLKQCFSLP

Ligand information

Ligand ID

PHI

InChI

InChI=1S/C9H10INO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1

InChIKey

PZNQZSRPDOEBMS-QMMMGPOBSA-N

SMILES

Software	SMILES
CACTVS 3.341	N[CH](Cc1ccc(I)cc1)C(O)=O
CACTVS 3.341	N[C@@H](Cc1ccc(I)cc1)C(O)=O
OpenEye OEToolkits 1.5.0	c1cc(ccc1CC(C(=O)O)N)I
OpenEye OEToolkits 1.5.0	c1cc(ccc1C[C@@H](C(=O)O)N)I
ACDLabs 10.04	Ic1ccc(cc1)CC(C(=O)O)N

Formula

C9 H10 I N O2

Name

IODO-PHENYLALANINE

PDB chain

1orw Chain D Residue 807 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	1orw The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism
Resolution	2.84 Å
Binding residue (original residue number in PDB)	R125 E205 E206 F357 R358 Y662 N710
Binding residue (residue number reindexed from 1)	R87 E167 E168 F319 R320 Y624 N672
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	Y547 S630 Y631 D708 H740
Catalytic site (residue number reindexed from 1)	Y509 S592 Y593 D670 H702
Enzyme Commision number	3.4.14.5: dipeptidyl-peptidase IV.

Gene Ontology

	Molecular Function
GO:0002020	protease binding
GO:0004177	aminopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005102	signaling receptor binding
GO:0008236	serine-type peptidase activity
GO:0008239	dipeptidyl-peptidase activity
GO:0042803	protein homodimerization activity

	Biological Process
GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0008284	positive regulation of cell population proliferation
GO:0010716	negative regulation of extracellular matrix disassembly
GO:0031295	T cell costimulation
GO:0043542	endothelial cell migration

	Cellular Component
GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016324	apical plasma membrane
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0031258	lamellipodium membrane
GO:0042995	cell projection
GO:0045121	membrane raft
GO:0070161	anchoring junction

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:1orw, PDBe:1orw, PDBj:1orw
PDBsum	1orw
PubMed	12690074
UniProt	P22411\|DPP4_PIG Dipeptidyl peptidase 4 (Gene Name=DPP4)

[Back to BioLiP]