Structure of PDB 1msw Chain D Binding Site BS01

Receptor Information
>1msw Chain D (length=863) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARF
RKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPT
AFQFLQEIKPEAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARF
GRIRDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAW
SSWHKEDSIHVGVRCIEMLIESTGMVSLHRQSETIELAPEYAEAIATRAG
ALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYE
DVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPAIEREE
LPMKTAWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNM
DWRGRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGV
DKVPFPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAG
VQHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDI
YGIVAKKVNEILQADAINGTDNEVVTVTDENTGEISEKVKLGTKALAGQW
LAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQP
NQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILR
KRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQFRLQPTINTNKDSEID
AHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIESFALIHDSFGTIPAD
AANLFKAVRETMVDTYESCDVLADFYDQFADQLHESQLDKMPALPAKGNL
NLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB1msw Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
Resolution2.1 Å
Binding residue
(original residue number in PDB)		R57 R298 H300 R357 K392 D421 W422 R423 Y427 M431 T636 Y639 F644 G645 Y739 H772 S776 P780
Binding residue
(residue number reindexed from 1)		R56 R289 H291 R348 K372 D401 W402 R403 Y407 M411 T616 Y619 F624 G625 Y719 H752 S756 P760
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1msw, PDBe:1msw, PDBj:1msw
PDBsum1msw
PubMed12242451
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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