Structure of PDB 1lph Chain D Binding Site BS01

Receptor Information
>1lph Chain D (length=30) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVNQHLCGSHLVEALYLVCGERGFFYTKPT
Ligand information
>1lph Chain C (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1lph Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Q4 C7 L11 V18 C19 R22 G23 F25
Binding residue
(residue number reindexed from 1)		Q4 C7 L11 V18 C19 R22 G23 F25
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005179 hormone activity
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1lph, PDBe:1lph, PDBj:1lph
PDBsum1lph
PubMed8590022
UniProtP01308|INS_HUMAN Insulin (Gene Name=INS)

[Back to BioLiP]