Structure of PDB 1k74 Chain D Binding Site BS01

Receptor Information

>1k74 Chain D (length=272) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPG
FVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKS
LRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKP
IEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQV
IKKTETDMSLHPLLQEIYKDLY

Ligand information

>1k74 Chain E (length=16) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ERHKILHRLLQEGSPS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1k74 Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	Q294 T297 K301 Q314 V315 L318 K319 L468 E471
Binding residue (residue number reindexed from 1)	Q89 T92 K96 Q109 V110 L113 K114 L263 E266

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:1k74, PDBe:1k74, PDBj:1k74
PDBsum	1k74
PubMed	11698662
UniProt	P37231\|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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