Structure of PDB 1jfz Chain D Binding Site BS01

Receptor Information
>1jfz Chain D (length=148) Species: 63363 (Aquifex aeolicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMKMLEQLEKKLGYTFKDKSLLEKALTHVSYSKKEHYETLEFLGDALVNF
FIVDLLVQYSPNKREGFLSPLKAYLISEEFFNLLAQKLELHKFIRIKRGK
INETIIGDVFEALWAAVYIDSGRDANFTRELFYKLFKEDILSAIKEGR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1jfz Chain D Residue 764 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1jfz Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		E640 D707 E710
Binding residue
(residue number reindexed from 1)		E41 D108 E111
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology
Molecular Function
GO:0004525 ribonuclease III activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:1jfz, PDBe:1jfz, PDBj:1jfz
PDBsum1jfz
PubMed11738048
UniProtO67082|RNC_AQUAE Ribonuclease 3 (Gene Name=rnc)

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