Structure of PDB 1i6v Chain D Binding Site BS01

Receptor Information
>1i6v Chain D (length=1174) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVRKVRIALASPEKIRSWSYGEVEKPETEAKVCERCAVEVTRSIVRRYR
MAHIELATPAAHIWFVKDVPSKIATLLDLSATELEQVLYFNKYIVLDPKA
AVLDAVPVEKRQLLTDAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAIDARMGAEAIQELLKELDLEKLERELLEEMKHPSRARRAKARKRLEVV
RAFLDSGNRPEWMILEAVPVLPPDATSDLNDLYRRLINRNNRLKKLLAQG
APEIIIRNEKRMLQEAVDAVIDNGRRGSPVTNPGSERPLRSLTDILSGKQ
GRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKM
EEKAFAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRL
GIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARI
QMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGMAFATPEE
ALAAYERGEVALNAPIVVAGRETSVGRLKFVFANPDEALLAVAHGLLDLQ
DTVTTRYLGRRLETSPGRILFARIVGEAVGDEKVAQELIQMDVPQEKNSL
KDLVYQAFLRLGMEKTARLLDALKYYGFTLSTTSGITIGIDDAVIPEEKQ
RYLEEADRKLRQIEQAYEMGFLTDRERYDQVIQLWTETTEKVTQAVFNNF
EENYPFNPLYVMAQSGARGNPQQIRQLCGMRGLMQKPSGETFEVPVRSSF
REGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVAHEIVVREAD
CGTTNYISVPLFQMDEVTRTLRLRKRSDIESGLYGRVLAREVEALGRRLE
EGRYLSLEDVHFLIKAAEAGEVREVPVRSPLTCQTRYGVCQKCYGYDLSM
ARPVSIGEAVGVVAAESIGEPGTQLTMRTGTDITQGLPRVIELFEARRPK
AKAVISEIDGVVRIEEGEDRLSVFVESEGFSKEYKLPKDARLLVKDGDYV
EAGQPLTRGAIDPHQLLEAKGPEAVERYLVDEIQKVYRAQGVKLHDKHIE
IVVRQMLKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAVPVAWKPLLM
GVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLI
PAGTGSDFVRFTQVVDQRTLKAIE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1i6v Chain D Residue 1600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1i6v Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D741 D743
Binding residue
(residue number reindexed from 1)		D430 D432
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1i6v, PDBe:1i6v, PDBj:1i6v
PDBsum1i6v
PubMed11290327
UniProtQ9KWU6|RPOC_THEAQ DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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