Structure of PDB 1hqm Chain D Binding Site BS01

Receptor Information
>1hqm Chain D (length=1175) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVRKVRIALASPEKIRSWSYGEVEKPETEGKVCERCGVEVTRSIVRRYR
MGHIELATPAAHIWFVKDVPSKIGTLLDLFATELEQVLYFNKYIVLDPKG
AVLDGVPVEKRQLLTDAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAIDARMGAEAIQELLKELDLEKLERELLEEMKHPSRARRAKARKRLEVV
RAFLDSGNRPEWMILEAVPVLPPDATSDLNDLYRRLINRNNRLKKLLAQG
APEIIIRNEKRMLQEAVDAVIDNGRRGSPVTNPGSERPLRSLTDILSGKQ
GRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKM
EEKAFAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRL
GIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARI
QMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGMAFATPEE
ALAAYERGEVALNAPIVVAGRETSVGRLKFVFANPDEALLAVAHGLLDLQ
DTVTTRYLGRRLETNPGRILFARIVGEAVGDEKVAQELIQMDVPQEKNSL
KDLVYQAFLRLGMEKTARLLDALKYYGFTLSTTSGIITIGIDDAVIPEEK
QRYLEEADRKLRQIEQAYEMGFLTDRERYDQVIQLWTETTEKVTQAVFNN
FEENYPFNPLYVMAQSGARGNPQQIRQLCGMRGLMQKPSGETFEVPVRSS
FREGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVAHEIVVREA
DCGTTKYISVPLFQMDEVTRTLRLRKRSDIESGLYGRVLAREVEALGRRL
EEGRYLSLEDVHFLIKAAEAGEVREVPVRSPLTCQTRYGVCQKCYGYDLS
MARPVSIGEAVGVVAAESIGEPGTQLTMRTGTDITQGLPRVIELFEARRP
KAKAVISEIDGVVRIEEGEDRLSVFVESEGFSKEYKLPKDARLLVKDGDY
VEAGQPLTRGAIDPHQLLEAKGPEAVERYLVDEIQKVYRAQGVKLHDKHI
EIVVRQMLKYVEVTDPGDSPLLEGQVLEKWDVEALNERLIAVPVAWKPLL
MGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRL
IPAGTGSDFVRFTQVVDQRTLKAIE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1hqm Chain D Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1hqm Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D739 D741 D743
Binding residue
(residue number reindexed from 1)		D428 D430 D432
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1hqm, PDBe:1hqm, PDBj:1hqm
PDBsum1hqm
PubMed11158566
UniProtQ9KWU6|RPOC_THEAQ DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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