Structure of PDB 1h1c Chain D Binding Site BS01

Receptor Information
>1h1c Chain D (length=329) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IAKRAYPYETEKRDKTYLALNENPFPFPEDLVDEVFRRLNSDALRIYYDS
PDEELIEKILSYLDTDFLSKNNVSVGNGADEIIYVMMLMFDRSVFFPPTY
SCYRIFAKAVGAKFLEVPLTKDLRIPEVNVGEGDVVFIPNPNNPTGHVFE
REEIERILKTGAFVALDEAYYEFHGESYVDFLKKYENLAVIRTFSKAFSL
AAQRVGYVVASEKFIDAYNRVRLPFNVSYVSQMFAKVALDHREIFEERTK
FIVEERERMKSALREMGYRITDSRGNFVFVFMEKEEKERLLEHLRTKNVA
VRSFREGVRITIGKREENDMILRELEVFK
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1h1c Chain D Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1h1c Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase
Resolution2.85 Å
Binding residue
(original residue number in PDB)		G84 A85 D86 Y106 D173 Y176 T199 S201 K202 R210
Binding residue
(residue number reindexed from 1)		G78 A79 D80 Y100 D167 Y170 T193 S195 K196 R204
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.9: histidinol-phosphate transaminase.
Gene Ontology
Molecular Function
GO:0004400 histidinol-phosphate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1h1c, PDBe:1h1c, PDBj:1h1c
PDBsum1h1c
PubMed15007066
UniProtQ9X0D0|HIS8_THEMA Histidinol-phosphate aminotransferase (Gene Name=hisC)

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