Structure of PDB 1gqt Chain D Binding Site BS01

Receptor Information

>1gqt Chain D (length=305) Species: 83333 (Escherichia coli K-12)

AGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGR
SGANIAFIACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVN
GEGENVIGIHAGANAALSPALVEAQRERIANASALLMQLESPLESVMAAA
KIAHQNKTIVALNPAPARELPDELLALVDIITPNETEAEKLTGIRVENDE
DAAKAAQVLHEKGIRTVLITLGSRGVWASVNGEGQRVPGFRVQAVDTIAA
GDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVPWREEIDA
FLDRQ

Ligand information

• Ligand ID: CS
• InChI: InChI=1S/Cs/q+1
• InChIKey: NCMHKCKGHRPLCM-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Cs+]
• Formula: Cs
• Name: CESIUM ION
• PDB chain: 1gqt Chain D Residue 1309

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1gqt Activation of Ribokinase by Monovalent Cations.
• Resolution: 2.34 Å
• Binding residue (original residue number in PDB): D249 I251 A285 R288 S294
• Binding residue (residue number reindexed from 1): D246 I248 A282 R285 S291
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): A252 A253 G254 D255
• Catalytic site (residue number reindexed from 1): A249 A250 G251 D252
• Enzyme Commision number: 2.7.1.15: ribokinase.

Gene Ontology

Molecular Function

• GO:0004747 ribokinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006014 D-ribose metabolic process
• GO:0016310 phosphorylation
• GO:0019303 D-ribose catabolic process
• GO:0046835 carbohydrate phosphorylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1gqt, PDBe:1gqt, PDBj:1gqt
• PDBsum: 1gqt
• PubMed: 11786021
• UniProt: P0A9J6|RBSK_ECOLI Ribokinase (Gene Name=rbsK)