Structure of PDB 1fuj Chain D Binding Site BS01

Receptor Information

>1fuj Chain D (length=221) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIP
QRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDILLIQLSSP
ANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTV
VTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATR
LFPDFFTRVALYVDWIRSTLR

Ligand information

Ligand ID

FUC

InChI

InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1

InChIKey

SHZGCJCMOBCMKK-SXUWKVJYSA-N

SMILES

Software	SMILES
CACTVS 3.341	C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04	OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0	CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0	C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341	C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O

Formula

C6 H12 O5

Name

alpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose

PDB chain

1fuj Chain H Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1fuj The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	Q135 L137 I200 C201 D202
Binding residue (residue number reindexed from 1)	Q124 L126 I181 C182 D183
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D102 F192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)	H44 D91 F173 G174 D175 S176 G177
Enzyme Commision number	3.4.21.76: myeloblastin.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005102	signaling receptor binding
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0019899	enzyme binding

	Biological Process
GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0008284	positive regulation of cell population proliferation
GO:0019730	antimicrobial humoral response
GO:0030574	collagen catabolic process
GO:0043547	positive regulation of GTPase activity
GO:0045217	cell-cell junction maintenance
GO:0050765	negative regulation of phagocytosis
GO:0072672	neutrophil extravasation
GO:0097029	mature conventional dendritic cell differentiation

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0035578	azurophil granule lumen
GO:0043231	intracellular membrane-bounded organelle
GO:0044853	plasma membrane raft
GO:0045121	membrane raft
GO:0062023	collagen-containing extracellular matrix
GO:0070062	extracellular exosome

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1fuj, PDBe:1fuj, PDBj:1fuj
PDBsum	1fuj
PubMed	8757293
UniProt	P24158\|PRTN3_HUMAN Myeloblastin (Gene Name=PRTN3)

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