Structure of PDB 1d8w Chain D Binding Site BS01

Receptor Information
>1d8w Chain D (length=403) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTTQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVSGFEY
PGKARNASELRADLEQAMRLIPGPKRLNLHAIYLESDTPVSRDQIKPEHF
KNWVEWAKANQLGLDFNPSCFSHPLSADGFTLSHADDSIRQFWIDHCKAS
RRVSAYFGEQLGTPSVMNIWIPDGMKDITVDRLAPRQRLLAALDEVISEK
LNPAHHIDAVESKLFGIGAESYTVGSNEFYMGYATSRQTALCLDAGHFHP
TEVISDKISAAMLYVPQLLLHVSRPVRWDSDHVVLLDDETQAIASEIVRH
DLFDRVHIGLDFFDASINRIAAWVIGTRNMKKALLRALLEPTAELRKLEA
PGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPAGSEWLESVRAYEKEIL
SRR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1d8w Chain D Residue 450 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1d8w The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		E234 D267 H294 D334
Binding residue
(residue number reindexed from 1)		E211 D244 H271 D311
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) W193 E234 K236 D267 H270 H294 D302 D304 D334
Catalytic site (residue number reindexed from 1) W170 E211 K213 D244 H247 H271 D279 D281 D311
Enzyme Commision number 5.3.1.14: L-rhamnose isomerase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008740 L-rhamnose isomerase activity
GO:0016853 isomerase activity
GO:0030145 manganese ion binding
GO:0033296 rhamnose binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0019299 rhamnose metabolic process
GO:0019301 rhamnose catabolic process
GO:0019324 L-lyxose metabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1d8w, PDBe:1d8w, PDBj:1d8w
PDBsum1d8w
PubMed10891278
UniProtP32170|RHAA_ECOLI L-rhamnose isomerase (Gene Name=rhaA)

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