Structure of PDB 1d01 Chain D Binding Site BS01
Receptor Information
>1d01 Chain D (length=168) Species:
9606
(Homo sapiens) [
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AMADLEQKVLEMEASTYDGVFIWKISDFPRKRQEAVAGRIPAIFSPAFYT
SRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLM
LLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNS
YVRDDAIFIKAIVDLTGL
Ligand information
>1d01 Chain G (length=8) Species:
9606
(Homo sapiens) [
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MLSVEEEG
Receptor-Ligand Complex Structure
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PDB
1d01
The structural basis for the recognition of diverse receptor sequences by TRAF2.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
R393 Y395 D399 G400 F410 A446 F447 R448 D450 S453 F456 A466 S467 G468
Binding residue
(residue number reindexed from 1)
R60 Y62 D66 G67 F77 A113 F114 R115 D117 S120 F123 A133 S134 G135
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842
ubiquitin-protein transferase activity
GO:0005164
tumor necrosis factor receptor binding
Biological Process
GO:0007250
activation of NF-kappaB-inducing kinase activity
GO:0033209
tumor necrosis factor-mediated signaling pathway
GO:0042981
regulation of apoptotic process
GO:0046328
regulation of JNK cascade
GO:0051865
protein autoubiquitination
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Molecular Function
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Biological Process
External links
PDB
RCSB:1d01
,
PDBe:1d01
,
PDBj:1d01
PDBsum
1d01
PubMed
10518213
UniProt
Q12933
|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)
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