Structure of PDB 7pub Chain Cv Binding Site BS01

Receptor Information
>7pub Chain Cv (length=1040) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PIEFRFYQRYANHPNRQSGIQFLTHYNTHQRFRVNKDYIDYMHWGKEQGQ
ARLPHRHQRVAFDFNDQLHPTRIGYAWFASQDPTFGHHPDLSSSFDPNYR
VFSHPEHWNKMFTKRRPGEGDIDLSVLPSRSLLGPLMAHSDTKGIPYFKV
DNRGHSNGRVPGVNAPFFGEFDQKMMQAMSRPLNANRTITGNDGRFSKTI
MINEPQCNQALSAKTASELSKEIDKATNAVYSKLSVLEAAQSGLTDYFCG
GLNFEIVGFELHMAAMLRERAAAILERSGACAMLLEKADEREVNKLLRDA
SRYEDRVDDALRQHASLIWRVYTAPRPLMTLTNGKCRGTGCGLSLFAKYC
ALKDSSEFIFDGPNVGITPYGGMTRLLARPETSLKYPGLAEFVVLTGASL
FAGDALRLGWTDLFTTIPDMTYHIKEWFDTTEHMHNDAVAWQLGHLLETC
FKMKESHSSAMERAAITPTRARWVEDAFADQPSVNDIMRTLTEIEQLPFQ
STHNTSDESHITPYTLGSVAAGVQRLGEHRLRYTLSPWDITPPEDSVVLK
HTSEMFRAYVLERRGATDVVTHRDAERAAAWSQQRQREYDAYCSLKEAPH
PRHVYARLEGCEGKIVSFEFVFEITTISRLKSRILDALGMPRDRNIDLGW
YLPTLDTCPIHSDEELMQVLHTDPGIEDPKEKLRYPPIYFIVKRCTLYFS
EWAYAVKHQLLLQSPFALRAAFGLLQEVRGDGAAENVMPLAETLGTEFKY
FTRLMRRPDFYRVGVHTDKSVEKWEEIKEERRHNIHHTHRPTRPLPDFEE
VFERDVEIDGHRFVLRPRWNPRTLQDVDDSDILRLRAPLTYDMDSTAALH
VPTHCGKASRLAGMLQDAGGVQVLDGLGEVDDKGEPKVPPLQSNASVPTN
VSFYEMARHPWEDRASSWRRDGFTEGSLEYFESQYRSAERAVYDEEGRGV
RNYWPSRDAVEGIAQEEENDAQLLQERLFNTLETAGTSVEPWARNLRLNA
TTGKFGYKTEIATQEEKIYDDEYYRWFIQPGRHPNPSGLT
Ligand information
>7pub Chain CA (length=621) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaaauuauggucaauuguuaguauucauauuaauuuuuuuaaauguuuua
ucauuuuauaaagguuuauuuuugaaagauuuuuuguauaaaauuuuagg
aauaguuaauaauaauuuauaauuuugauuagauuguuuuguuaaugcua
uuagauggguguggaaaaauaaaaaaaauaauuaauauauaucaauaaua
aauuaaauuaaucuauuagucagaaauggaugccagccguugcgguaauu
ucuaugcuuuuaaauauuauacaauuaucauauuaaauuguuaagugcug
auuuaaccaauaaaaauauaaauaauuuuuauuuguuuuuaaacaccauu
agguauaugcaaauauaaaauuauaguaauuauaaauuauauuauauuau
auuuauucauauaauuaauaggauaauauuuguaguuuuugauaccauga
uaaggauuauaaauugaaaguguuaauaucauaaucaaaauuuauuauuu
auauuaaauauguauguguagauaaaauaagaaauuaaaaagguauuguu
gcccaccaauuuuuauaauaaaaauaacgugcaguaauuaauauauuuau
aaaaauauauuuuuuuuuuuu
....................<<<.......<<<<<<............<.
..>..........................................<....
.<<...<<<.......>>>..>>........>........<<....>>..
..................................................
.................<<<.....<<<<<.....<<....>>.......
>>>>>>>>....>>.>>>>...............................
..................................................
..............................>>>....<............
.<<<<<............................................
..................................................
.....................>>>>>..................>.....
<<.<<<..<<<<<<.....>>>>>>...>>>..>>....<<<<<<<<<..
..>>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7pub Mitoribosomal small subunit maturation involves formation of initiation-like complexes.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R44 Y46 Q47 R48 A50 H52 P53 R55 I59 R72 R240 P241 L242
Binding residue
(residue number reindexed from 1)		R5 Y7 Q8 R9 A11 H13 P14 R16 I20 R33 R181 P182 L183
Enzymatic activity
Enzyme Commision number 3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase.
Gene Ontology
Molecular Function
GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006635 fatty acid beta-oxidation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pub, PDBe:7pub, PDBj:7pub
PDBsum7pub
PubMed35042777
UniProtQ383R4

[Back to BioLiP]