Structure of PDB 6rxx Chain Cq Binding Site BS01

Receptor Information

>6rxx Chain Cq (length=81) Species: 209285 (Thermochaetoides thermophila)

VLAVDLLNPSPASEARKHKLKTLVPAPRSFFMDVKCPGCFTITTVFSHAQ
TVVICQGCTNVLCQPTGGKARLTEGCSFRRK

Ligand information

>6rxx Chain C1 (length=1221)

ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgggcucugugggugggggaauucaggag
gggaaaacgauaguuaccugguugauucugcuagucauaugcuugucuca
aauaagccaugcgucuaaguauaagcaauuauacagcgaaacugcgaaug
gcucauuaaaucaguuaucguuuauuugauaguaccuuacuacauggaua
accgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaag
ggauguauuuauuagauuaaaaaccaaugcccuucggggcggugauucau
aauaacuucucgaaucgcacggccuuggccggcgaugguucauucaaauu
ucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaa
cggguaaggguuagggcucggagaaggagccugagaaacggcuacuacau
ccaaggaagggcaggcgcgcaaauuacccaaucccgacacggggagguag
ugacaauaaauacugauacagggcucuuucgggucuuguaauuggaauga
guacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugc
cagcagccgcgguaauuccagcuccaauagcguauauugcucguaguuga
accugggccuagcccgccgguccgccucaccgcgugcacuggcugggcug
ggccugauuaauagggacagucgggggcgucaguauucaauugucagagg
ugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaa
ggauguuuucauuaaucaggaacguaaacuauuagggaucggacggcguu
uauuuuugacccguucggcaccuuacgauaggaguauggucgcaaggcug
aaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuac
acugacagagccagcgaguacucccuuggccgagaggcccggguaaucuu
guuaaacucugucgugcuggggauagagcauugcaauuauugcucuucaa
cgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguagguc
uccguaggugaaccugcggag

<<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>
>.>>>>............................................
.................................<<.<<<<<<...<.<<.
.....<<<.<<<<<....<<....<<.........>>...>>.>>.....
.<<<.......<<<..<<..<<....<<<...............<<..<.
.<..<<.......>>..>.....>>>........<<<<<..........>
>>>><...<<<<<<..............<<<<<..>>>>>.........>
>>>>>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>.
.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>.....
.>>>...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<
<<..>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>..
.>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....
<<..<...........>..>>.........<<<<<<.......<<<....
>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<
<...<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>
>>>>>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<.
.....>>>......>.>>>>>>.>>>.......<<....>>...>>>>..
>>.>>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<
.......>>>>>>>>>>>..>>............................
.......<<<<<<<<<<<<..<<.<<<<<<..<<<..........>>>..
...<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.
......>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<
<<<<<<<<....>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rxx Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
• Resolution: 7.1 Å
• Binding residue (original residue number in PDB): R17 K18 H19 S30 F31 F32 V46 F47 H49 Q51 P66 T67 G68 G69 K70
• Binding residue (residue number reindexed from 1): R16 K17 H18 S29 F30 F31 V45 F46 H48 Q50 P65 T66 G67 G68 K69

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit

External links

• PDB: RCSB:6rxx, PDBe:6rxx, PDBj:6rxx
• PDBsum: 6rxx
• PubMed: 31378463
• UniProt: G0S1S4